A critique of current CAL research

This paper examines what is wrong with current CAL research and its literature. The principal problem Is that CAL research has developed horizontally. but not vertically. This is reflected in the literature which contains a plethora of specific implementations of CAL but few attempts to draw any generalisations from these that might advance our understanding of CAL. This is attributed to the fact that two fundamental questions about CAL are not asked: those questions being ·When should CAL be used? and ·What constitutes good CAL? . The absence of these questions is. in turn. attributed to a false bias amongst CAL researchers which leads them to be more concerned that their work uses computers than that It has direct educational benefit

Images under control: pessimism, humour and stupidity in the digital age

This thesis offers a periodization of the present according to which contemporary art and visual culture are understood to be symptomatic of an increasingly pervasive pessimistic social, political and ecological outlook. This pessimism I will claim is what is authentically new about our contemporary cultural forms, which are directed towards a particular form of humour and stupidity. Core elements in the periodization include the limitation of imaginative horizons expressed in the well-known remark of Fredric Jameson’s that it is easier to imagine the end of the world than the end of capitalism, as well as the pervasive sense that nature is in a state of perpetual and endemic crisis and the idea that modern computing technology is making us stupider than we have ever been before. I argue that these issues are symptomatic of what Gilles Deleuze, in 1990, termed the societies of Control – a world of corporate power, ubiquitous computing, data extraction and financial capitalism that has intensified since its early diagnosis. However, dominant narratives of art and visual culture continue to theorize artistic production according to traditionally avant-garde categories of resistance, criticality, transgression and subversion. This presumes art to have an agency that is difficult to imagine in the current social situation. In this respect, the thesis in part constitutes a critical reflection on the pressures placed upon our existing models of art and visual culture - for example, and centrally, the idea of an ‘avant-garde’ - by current social and technological conditions. Building on these observations, the thesis proposes a new model of contemporary art and visual culture that has no agency: images under control that are formed, as epiphenomena, by technological apparatuses of Control; studying examples such as extreme sports stunts, internet memes, online trolls, bad quality jpegs and impassive ‘artworks’. The purpose is to ask what value we can place on these emergent cultural forms, which seem to mirror, reflect and reiterate a pessimistic worldview deeply entrenched in the societies of Control

The virtual design studio: developing new tools for learning, practice and research in design.

The emergence of new networked technologies such as virtual learning environments (VLEs) and digital libraries are providing opportunities for the development of new virtual tools to assist the design researcher in exploring ideas with the aid of visualising and mapping tools and to provide interfaces that support interdisciplinary collaboration between design teams. In 1998 a research project was initiated to evaluate the potential of computer assisted learning within Art and Design. This resulted in the development of a virtual learning environment designed to support Art and Design students and staff (www.studio-space.net). This paper describes the design process used to develop this VLE and the underlying principles based on a constructivist approach to experiential learning. The on-going research uses the metaphor of the design studio to explore a range of technologies that provide generative tools for the representation of design practice and related research, including the development and evaluation of an online Personal Development Planning tool (PDP) and other information management systems. The paper explores some of the ways in which tools such as; information retrieval applications, white-boards, visual mapping and digital archives can be combined to provide a virtual online design research studio. A further extension to the metaphor provides opportunities for developing new facilities, for example the portfolio, drawing board, bookcase, modelmaking area. The virtual design studio has two potential uses: first, to provide a tool box for the design researcher/educator to undertake collaborative design practice using CAD/CAM applications; second, to provide systems that help to externalise design methodologies, thus making it possible to gain an insight into the design process itself. This latter outcome can be achieved through the use of meta data (such as author, date/time created, version number - i.e. design iteration, note pad) and the representation of critical decision paths and reflection points

Rare coding variants and X-linked loci associated with age at menarche.

More than 100 loci have been identified for age at menarche by genome-wide association studies; however, collectively these explain only ∼3% of the trait variance. Here we test two overlooked sources of variation in 192,974 European ancestry women: low-frequency protein-coding variants and X-chromosome variants. Five missense/nonsense variants (in ALMS1/LAMB2/TNRC6A/TACR3/PRKAG1) are associated with age at menarche (minor allele frequencies 0.08-4.6%; effect sizes 0.08-1.25 years per allele; P<5 × 10(-8)). In addition, we identify common X-chromosome loci at IGSF1 (rs762080, P=9.4 × 10(-13)) and FAAH2 (rs5914101, P=4.9 × 10(-10)). Highlighted genes implicate cellular energy homeostasis, post-transcriptional gene silencing and fatty-acid amide signalling. A frequently reported mutation in TACR3 for idiopathic hypogonatrophic hypogonadism (p.W275X) is associated with 1.25-year-later menarche (P=2.8 × 10(-11)), illustrating the utility of population studies to estimate the penetrance of reportedly pathogenic mutations. Collectively, these novel variants explain ∼0.5% variance, indicating that these overlooked sources of variation do not substantially explain the 'missing heritability' of this complex trait.UK sponsors (see article for overseas ones): This work made use of data and samples generated by the 1958 Birth Cohort (NCDS). Access to these resources was enabled via the 58READIE Project funded by Wellcome Trust and Medical Research Council (grant numbers WT095219MA and G1001799). A full list of the financial, institutional and personal contributions to the development of the 1958 Birth Cohort Biomedical resource is available at http://www2.le.ac.uk/projects/birthcohort. Genotyping was undertaken as part of the Wellcome Trust Case-Control Consortium (WTCCC) under Wellcome Trust award 076113, and a full list of the investigators who contributed to the generation of the data is available at www.wtccc.org.uk ... The Fenland Study is funded by the Wellcome Trust and the Medical Research Council, as well as by the Support for Science Funding programme and CamStrad. ... SIBS - CRUK ref: C1287/A8459 SEARCH - CRUK ref: A490/A10124 EMBRACE is supported by Cancer Research UK Grants C1287/A10118, C1287/A16563 and C1287/A17523. Genotyping was supported by Cancer Research - UK grant C12292/A11174D and C8197/A16565. Gareth Evans and Fiona Lalloo are supported by an NIHR grant to the Biomedical Research Centre, Manchester. The Investigators at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust are supported by an NIHR grant to the Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. Ros Eeles and Elizabeth Bancroft are supported by Cancer Research UK Grant C5047/A8385. ... Generation Scotland - Scottish Executive Health Department, Chief Scientist Office, grant number CZD/16/6. Exome array genotyping for GS:SFHS was funded by the Medical Research Council UK. 23andMe - This work was supported in part by NIH Award 2R44HG006981-02 from the National Human Genome Research Institute.This is the final version of the article. It first appeared from NPG via http://dx.doi.org/10.1038/ncomms875

Rare and low-frequency coding variants alter human adult height

Height is a highly heritable, classic polygenic trait with ~700 common associated variants identified so far through genome - wide association studies . Here , we report 83 height - associated coding variants with lower minor allele frequenc ies ( range of 0.1 - 4.8% ) and effects of up to 2 16 cm /allele ( e.g. in IHH , STC2 , AR and CRISPLD2 ) , >10 times the average effect of common variants . In functional follow - up studies, rare height - increasing alleles of STC2 (+1 - 2 cm/allele) compromise d proteolytic inhibition of PAPP - A and increased cleavage of IGFBP - 4 in vitro , resulting in higher bioavailability of insulin - like growth factors . The se 83 height - associated variants overlap genes mutated in monogenic growth disorders and highlight new biological candidates ( e.g. ADAMTS3, IL11RA, NOX4 ) and pathways ( e.g . proteoglycan/ glycosaminoglycan synthesis ) involved in growth . Our results demonstrate that sufficiently large sample sizes can uncover rare and low - frequency variants of moderate to large effect associated with polygenic human phenotypes , and that these variants implicate relevant genes and pathways

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC

Common germline polymorphisms associated with breast cancer-specific survival

Abstract Introduction Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium. Methods A literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value <0.05 were included. Single nucleotide polymorphisms that had been previously reported as nominally associated with at least one survival outcome were evaluated in the pooled analysis of over 37,000 breast cancer cases for association with breast cancer-specific survival. Previous associations were evaluated using a one-sided test based on the reported direction of effect. Results Fifty-six variants from 45 previous publications were evaluated in the meta-analysis. Fifty-four of these were evaluated in the full set of 37,954 breast cancer cases with 2,900 events and the two additional variants were evaluated in a reduced sample size of 30,000 samples in order to ensure independence from the previously published studies. Five variants reached nominal significance (P <0.05) in the pooled GWAS data compared to 2.8 expected under the null hypothesis. Seven additional variants were associated (P <0.05) with ER-positive disease. Conclusions Although no variants reached genome-wide significance (P <5 x 10−8), these results suggest that there is some evidence of association between candidate common germline variants and breast cancer prognosis. Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels

The teaching of computing in schools

The paper considers five questions in the context of teaching computing in schools. (I) What Is computing? (II) Who should teach It ? (III) What training do they require? (Iv) Where and when should this training be given ? (v) How can this be achieved ? Based on an analysis of the first four points and a summary of the problems raised therein solutions are offerred which make use of the currently avallable over-supply of teachers and the endeavours of Colleges of Advanced Education to retain viability by expanding into new fields